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Between 1989 and 2012, brains obtained from autopsies of deceased patients at the Department of Neurology, University of Debrecen, were preserved in formalin. Additionally, for the majority of these cases, formalin-fixed, paraffin-embedded (FFPE) tissue blocks were prepared from well-documented, specific brain regions. These materials retain the molecular microenvironment characteristic of the deceased's disease, making them suitable for further fundamental research. Studies indicate that these samples are appropriate for identifying proteins, lipids, and carbohydrates present in the tissue through immunohistochemical or immunofluorescent methods. Molecular biological investigations, including DNA, RNA, exome, and genome sequencing, can also be conducted. These samples are particularly well-suited for glycomics research, as formalin fixation does not affect carbohydrate structures.

In addition to brain samples, numerous peripheral nerve and muscle biopsy specimens are available, which were obtained from living individuals for diagnostic purposes. These samples have been preserved by freezing in liquid nitrogen.

By systematically organizing these data, we have established a nervous system tissue bank at the Department of Neurology, University of Debrecen. Our objective is to provide central nervous system tissue samples to national and international research groups investigating the pathomechanisms of neuropsychiatric disorders. Our role is to select and provide appropriate samples, while the research teams are responsible for designing and conducting their respective research protocols.

The establishment of the nervous system tissue bank was made possible with the support of the University of Debrecen and Richter Gedeon Ltd.